Dermatopathology Case 155

Nodular swelling on right thigh for six months with rapid increase in size.

Skin covered pigmented nodular growth measuring 4.5 x 2 x 1.5 cm 

Cut surface - grey brown to tan in appearance with focal areas of haemorrhage.

 







Answer

 

 


 

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Large Cell Acanthoma Visit: Large cell Acanthoma Visit: Dermatopathology site Abstracts: A conjunctival lesion with histological features similar to large-cell acanthoma of the skin.J Cutan Pathol. 2009 Aug 27. Large-cell acanthoma (LCA) is a sharply demarcated epidermal lesion composed oflarge keratinocytes and characterized by hyperkeratosis, hypergranulosis and orthokeratosis. It usually affects actinically damaged skin. LCA is currentlybelieved to be a distinct entity with an unclear pathogenesis and a benign biologic behavior. Here, we describe the first occurrence of LCA in theconjunctiva. The lesion recurred following initial excision, and later recurred as a carcinoma in situ following a second excision. This case suggests that LCA may have a malignant and transformation potential. Ghazi NG, Patel BS, OlsakovskyLeslie A, White K, Patterson JW. A conjunctival lesion with histological features similar to large-cell acanthoma of the skin. Large cell acanthoma.Int J Dermatol . 2003
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